首页> 外国专利> 4-Piperidin-4-yliden-(3-karbamoylfenyl)metylbenzamidderivater og deres anvendelse ved behandling av smerte, spinalskader og gastrointestinale forstyrrelser

4-Piperidin-4-yliden-(3-karbamoylfenyl)metylbenzamidderivater og deres anvendelse ved behandling av smerte, spinalskader og gastrointestinale forstyrrelser

机译:4- [哌啶丁-4-亚烷基-(3-氨基甲酰基苯基)甲基]苯甲酰胺衍生物及其在治疗疼痛,脊柱损伤和胃肠道疾病中的用途

摘要

Diarilmetilen piperidine Derivatives of the General formula (1) wherein R1 is selected from any of tienilo pyridinyl, phenyl, furanilo, imidazolilo, pirrolilo triazolilo thiazolyl, and where each phenyl Ring; R1 and R1 heteroaromu00e1tico Ring can also be Optional and independientem Body replaced with 12 or 3 substituents independently selected from alkyl substituents C1 - 6 straight chain and branched alkoxy, NO2, CF3, C1 - 6, Chlorine, Fluorine, Bromine and iodine, as well as pharmaceutically acceptable salts of the same. The substitutions on the phenyl ring and the ring heteroaromu00e1tico may take place in any position on these Ring Systems.These compounds are useful in therapy, in particular for pain control. Use of these derivatives for the manufacture of medicinal products and Pharmaceutical composition.
机译:通式(1)的苯乙胺异戊二烯哌啶衍生物,其中R 1选自噻吩并吡啶基,苯基,呋喃基,咪唑啉,吡咯咯三唑并噻唑基,以及其中每个苯环; R1和R1杂芳环也可以是可选的,并且可以用12个或3个独立选自烷基取代基C1-6直链和支链烷氧基,NO2,CF3,C1-6的氯,氟,溴,碘取代的取代基取代,以及它们的药学上可接受的盐。苯环和环杂芳基上的取代可发生在这些环系统的任何位置。这些化合物可用于治疗,特别是用于控制疼痛。这些衍生物在制造医药产品和药物组合物中的用途。

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