Vaccine adjuvants for immunotherapy of melanoma

摘要

Use of IL-12 and antigen-presenting cells pulsed with peptide in the preparation of a medicament for inducing a mammalian immune response, wherein the antigen-presenting cells are not dendritic cells, a method of inducing an immune response in a non-human mammal comprising: a) providing a composition comprising IL-12; b) providing a composition comprising IL-12 and said composition comprising antigen-presenting cells pulsed with peptide to a non-human mammal in an amount effective to induce an immune response, wherein the antigen-presenting cells are not dendritic cells, a method of treating a non-human mammal with a disease comprising administering a composition comprising antigen-presenting cells pulsed with peptide wherein the antigen presenting cells are not dendritic cells and a composition comprising IL-12.