Compositions and methods for alleviating impaired mental function, memory loss and reducing recovery time in anaesthetized mammals

摘要

Composition and methods of alleviating impaired mental function and memory loss in mammals and reducing the recovery time from anaesthesia in age mammals, comprising treating the mammal with a non-toxic, enhancing effective amount of a cell membrane permeant calcium buffer, wherein the buffer is preferably a calcium ion chelating agent having a KD selected from the range 1x10-4 to 1x10-8 Molar and being essentially calcium ion-selective over other metal ions. A most preferred cell membrane permeant calcium buffer is bis (O-aminophenoxy)-ethane-N,N,N,N-tetraacetic acid-acetoxymethyl ester (BAPTA-AM).