Use of 17-ketosteroid compounds and derivatives, metabolites and precursors thereof in the treatment of hepatitis C virus and other togaviruses

摘要

A 17-ketosteroid derivative of formula (I) or the salts, stereoisomers, positional isomers, metabolites, analogs, precursors, hydrates, tautomers, ionized forms and solvates thereof is used in the manufacture of a medicament to treat or prevent togaviral infection, or to ameliorate or reduce one or more symptoms of a togaviral infection, in a subject suffering from or susceptible to the togaviral infection, In formula (I): Q1 is -C(R1)2- or -C(O)-; Q2 is -C(R1)2, -C(R1)(Y)-, -C(Y)- or CH2-CH2-; Q3 is -H or -C(R1)3-; Q4 is -C(R1)2-, -C(O)-, hydroxyvinylidine or methyl methylene; Q5 is -C(R1)2- or -C(O)-; Q6 is H, CH2OH or -C(R1)3- X and Y independently are -OH, -H, alkyl, -O-C(O)-R5, -C(O)-OR5, halogen or when a double bond exits between position 11 and -X, X is =O; each R1 independently is -H, halogen, -OH, alkoxy, or alkyl or at position 3 R1 is additionally OR53; R2 is-H, -OH, halogen, alkyl, alkoxy, -OR3, a fatty acid, alkynyl, (J)n-phenyl=alkyl, (J)n-phenyl-alkenyl, an ester, or -S- C(O)-(CH2)m-R4, -C(O)-S-(CH2)m-R4, -O-S(O)(O)-(CH2)m-R4, -O-S(O)(O)-O-(CH2)m-R4, -O-C(O)-NH-(CH2)m-R4, -NH-C(O)-O-(CH2)m-R4, -O-C(S)-(CH2)m-R4, -C(S)-O-(CH2)m-R4 or R2, together with the R1 that is bonded to the same carbon atom is =O; m is 0 to 3; R53, R3, R4, R5 are as defined in the specification and the dotted lines represent an optional double bond, provided that there are not double bonds at both the 4-5 and 5-6 positions and provided that when a double bond is present optionally an R1 group is bonded to carbon atoms at the 1-, 2-, 4-, 5- or -6 positions to satisfy the tetravalency of these carbon atoms provided that the compound is not dehydroepiandrosterone, dehydroepiandrosterone-3b-sulphate, 3b, 7b-dihydroandrost- 5-one or an ester or ether of any of these compounds..