17- USE OF 17-KETOSTEROID COMPOUNDS AND DERIVATIVES METABOLITES AND PRECURSORS THEREOF IN THE TREATMENT OF HEPATITIS C VIRUS AND OTHER TOGAVIRUSES

摘要

The present invention relates to 17-ketosteroid compounds, as well as derivatives, metabolites and precursors of these compounds, and pharmaceutically acceptable salts of any of these compounds, for the treatment of hepatitis C type virus and / or hepatitis G type virus, Collectively, there is provided the use of a compound referred to herein as a “compound of the invention”. Additionally, the present invention provides a method for the treatment or prevention of toga virus infection, including one or more alphaviruses, praviviruses such as yellow fever virus, hepatitis C virus and hepatitis G virus, rubella virus, or bovine Viral diarrhea infections caused by pestiviruses, such as viruses. Additionally, the present invention relates to the administration of one or more of the compounds of the present invention and a plasma concentration-promoting compound as described herein, and to one or more compounds selected from macrophage stimulating factors, oxidants, ribavirin and alpha interferon and / or oxygen supply. Provided is a combination therapy comprising administration. The compounds of the present invention may also alleviate or reduce one or more symptoms associated with togavirus infection.