Isolated anti-prostate stem cell antigen (PSCA) antibodies that internalise upon binding to PSCA on a mammalian cell, including a PSCA-expressing tumour cell, in vivo

摘要

Described are isolated anti-prostate stem cell antigen (PSCA) antibodies that internalize upon binding to PSCA on a mammalian in vivo. Compositions comprising an anti-PSCA antibody and a carrier are also provided. These compositions can be contained in an article of manufacture or a kit. Another aspect described is an isolated nucleic acid encoding an anti-PSCA antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-PSCA antibodies, and a method of producing the anti-PSCA antibodies. Other aspects include a method of killing a PSCA-expressing cancer cell, comprising contacting the cancer cell with an anti-PSCA antibody and a method of alleviating or treating a PSCA-expressing cancer in a non-human mammal, comprising administering a therapeutically effective amount of the anti-PSCA antibody to the mammal.