Indeno-, naphtho-, and benzocyclohepta-dihydrothiazole derivatives, the production thereof and their use as anorectic medicaments

摘要

The invention relates to compounds of the formula I (see below), wherein Y is a direct bond, X represents CH2, R1, R1' independently of one another are H, F, Cl, Br R2 is H, (C1-C6) R3 is H, F R4 represents (C8-C16) cycloalkyl, wherein one or more hydrogen(s) can be substituted in the alkyl groups by fluorine or a hydrogen can be substituted by OH, OC(O)CH3, OC(O)H, O-CH2-Ph or O-(C1-C4) alkyl; (CH2)n-A-R8, with n = 1-6, with the group -CH2-O-CH2-phenyl, wherein phenyl is unsubstituted, being excluded; (CH2)r-B-R9, with r = 1-6; A is O, S, SO, SO2; B is NH, N-(C1-C6) alkyl, NCHO, N(CO-CH3); R8 represents (C5-C24) alkyl, (C3-C10) cycloalkyl, wherein one or more hydrogen(s) can be substituted in the alkyl groups by fluorine or hydrogen can be substituted by OH, OC(O)CH3, OC(O)H, O-CH2-Ph or O-(C1-C4) alkyl; (CH2)m aryl, with m = 0-6, and aryl is phenyl, naphthyl, biphenyl, thienyl or pyridyl and the aryl part can be substituted up to two times; The invention also relates to the physiologically acceptable salts of compound I and to methods for producing them. The inventive compounds are suitable for use as anorectic agents, as a medicament for the prophylaxis and treatment of obesity and type II diabetes.