Pharmaceutical compositions comprising melatonin and an anti-hypertensive used to treat hypertension, vigilance and postponement of peak cortisol level

摘要

A pharmaceutical formulation, including both melatonin and at least one antihypertensive compound is described, in addition to a method, for treating a patient who is resistant to antihypertensives in absence of melatonin, a method for lowering nocturnal blood pressure in patients who have an abnormal rhythm in blood pressure in the absence or presence of antihypertensives, and a method for imparting in a patient at least one effect selected from improvement in mood and daytime vigilance, postponement of the peak level of cortisol in the patient and potential prophylactic protection against the detrimental effects of ischemia on the heart.