USE OF MELATONIN IN THE MANUFACTURE OF CONTROLLED RELEASE MEDICAMENTS FOR INPROVEMENT IN MOOD AND DAYTIME VIGILANCE, MODIFYING THE 24-HOUR CORTISOL PROFILE, PROTECTION AGAINST CARODIC ISCHEMIA, AND PREVENTION OR TREATMENT OF HYPERTENSION IN A PATIENT RESISTANT TO OTHER ANTIHYPERTENSIVE DRUGS

摘要

The invention relates to a pharmaceutical formulation, including both melatonin and at least one antihypertensive compound, as well as a method, for treating a patient who is resistant to antihypertensives in absence of melatonin, a method for lowering nocturnal blood pressure in patients who have an abnormal rhythm in blood pressure in the absence or presence of antihypertensives, and a method for imparting in a patient at least one effect selected from improvement in mood and daytime vigilance, postponement of the peak level of cortisol in the patient and potential prophylactic protection against the detrimental effects of ischemia on the heart, wherein melatonin is administered in an effective amount and manner.