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Stable, nasally, orally or sublingually applicable pharmaceutical preparation of desmopressin with malic acid used as the buffer
Stable, nasally, orally or sublingually applicable pharmaceutical preparation of desmopressin with malic acid used as the buffer
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机译:以苹果酸为缓冲液的去氨加压素的稳定,经鼻,经口或舌下适用的药物制剂
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摘要
A stable, nasally, orally or sublingually administrable pharmaceutical preparation for administration to patients in the form of a liquid solution contains desmopressin as the active ingredient, an osmotic agent and a malic acid buffer which maintains the pH value in the range from 4 to 6 for stabilising the desmopressin. The composition can be used for treating antidiuretic disorders such as nocturnal enuresis and diabetes insipidus, and for treating bleeding disorders such as haemophilia A, von Willebrand's disease and postoperative bleeding.
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