Therapeutic combinations comprising a selective estrogen receptor modulator and parathyroid hormone.

摘要

PCT No. PCT/IB99/00949 Sec. 371 Date Nov. 15, 1999 Sec. 102(e) Date Nov. 15, 1999 PCT Filed May 26, 1999 PCT Pub. No. WO99/65482 PCT Pub. Date Dec. 23, 1999This invention is directed to pharmaceutical combination compositions and methods comprising (-)-cis-6-phenyl-5-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-5,6,7,8-tetrahydronaphthalene-2-ol or a pharmaceutically acceptable salt thereof and parathyroid hormone or a biologically active fragment thereof, methods of using such compositions and kits containing such compositions. The compositions are useful for treating musculoskeletal frailty, including osteoporosis, osteoporotic fracture, low bone mass and frailty.