Pepper derivatives with ulterior motives such as antigonisas CCR5

摘要

It refers to a formula compound I, wherein N, s and T are 0, 1, 2, 3 or 4; the condition is that (I) n is 0, s is 2, t is 1, 3 or 4, and (II) n is 0, t is 2, s is 0, s is 0, 1, 3 or 4; X and Z are n or CH; R1 is h, asphalt, aralquilo, - S (O 2) asphalt, s (O2) asphalt, C (o) asphalt, C (o) arilo, heterosexual, 8 S (O2) cyclopentadiene, among others; R2, R4, R5, R6 and R7 may be the same or different, and are h or tar; R3 is h, tar, cyclopentadiene, aralquilo, isopropene, arilo or isopropene; or R2 and R3 together equal to n (or tar),=N (OH)=N-N (r20r21) or = CH (TAR), provided that when one or two X and Z are n, the addition of R2 and R3 is not equal to CH (TAR);R8 is arilo, tremolite, fluorine, diphenyl, isoaril-n-oxidation and other substitutes. It also refers to the composition of a drug used to treat HIV, including one or more of these compounds, which are selective CCR5 antagonists. In addition, they can also be used in combination with one or more antiviral agents or human immunodeficiency virus therapeutics, as well as in the treatment of rejection of solid-state organ transplantation, transplantation diseases and body type disorders, arthritis, rheumatoid arthritis, intestinal inflammation or Multiple sclerosis