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PROPHYLACTIC AND THERAPEUTIC USE OF OLTIPRAZ AS AN ANTIFIBROTIC AND ANTICIRRHOTIC AGENT IN THE LIVER AND PHARMACEUTICAL COMPOSITION CONTAINING OLTIPRAZ
PROPHYLACTIC AND THERAPEUTIC USE OF OLTIPRAZ AS AN ANTIFIBROTIC AND ANTICIRRHOTIC AGENT IN THE LIVER AND PHARMACEUTICAL COMPOSITION CONTAINING OLTIPRAZ
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机译:OLTIPRAZ在肝和含OLTIPRAZ的药物组合物中作为抗生和抗风湿剂的益生性和治疗性用途
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摘要
A pharmaceutical composition for prevention or treatment of progression of hepatic fibrosis and cirrhosis comprises 5-(2-Pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz). ACTIVITY : Hepatotropic; Cytostatic. MECHANISM OF ACTION : TGF-beta production inhibitor. A test was conducted on macrophage cells by adding oltipraz in a dose dependent manner. The results showed that oltipraz may function as an anti-fibrotic agent in hepatic kupffer cells by inhibiting TGF-beta production. The increase in TGF-beta expression was inhibited by EGTA or genistein which was an inhibitor of tyrosine kinase. The TGF-beta inhibition was 30%. This result shows that the inhibition of TGF-beta production by oltipraz may be the result of intracellular calcium regulation and changes in protein kinase activity.
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