METHODS AND COMPOSITIONS FOR IN-DEPTH DETECTIONS OF CANCER AND PRE-CANCER ORAL STATES

摘要

PCT No. PCT/US96/00509 Sec. 371 Date Sep. 3, 1997 Sec. 102(e) Date Sep. 3, 1997 PCT Filed Jan. 16, 1996 PCT Pub. No. WO97/26018 PCT Pub. Date Jul. 24, 1997A method for in-vivo detection of premalignant oral lesions and oral carcinomas includes the step of applying to oral tissue a non-toxic dye other than toluidine blue O, selected from compounds having structure IMAGE and ionic derivatives thereof, wherein R1 is H, or lower alkyl group or N(R3)2, R2 is N, S or O, and R3 is H or a lower alkyl group.