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RECEPTOR LSR ACTIVITY CLONING AND APPLICATIONS TO DIAGNOSIS PREVENTION AND / OR TREATMENT OF OBESITY AND ASSOCIATED RISKS OR COMPLICATIONS
RECEPTOR LSR ACTIVITY CLONING AND APPLICATIONS TO DIAGNOSIS PREVENTION AND / OR TREATMENT OF OBESITY AND ASSOCIATED RISKS OR COMPLICATIONS
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机译:受体LSR活性的克隆及其在肥胖的预防和/或治疗以及相关风险或并发症的诊断中的应用
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摘要
Purified LSR (lipolysis stimulated receptor) that binds lipoproteins (Lp) in presence of free fatty acids (FFA) and binds cytokines (Cy) in absence of FFA, is new. Independent claims are also included for the following: (1) purified, isolated or recombinant polypeptides (I) that make up LSR; (2) purified, isolated or recombinant nucleic acid (II) that encodes LSR or (I); (3) cloning and/or expression vectors containing (II); (4) host cells transformed with this vector; (5) non-human mammals containing a cell of (4); (6) recombinant production of (I); (7) mono- or poly-clonal or chimeric antibodies (Ab), or immunoconjugates that react specifically with (I) or LSR; (8) screening for (bio)chemicals (A) that interact with LSR; (9) (A); (10) use of Cy, specifically leptin, for modulating activity of LSR.
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