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Pharmaceutical composition for enhancing the specific elimination of pathogenic cells population, a composition for marking the pathogenic cells population and pharmaceutical composition
Pharmaceutical composition for enhancing the specific elimination of pathogenic cells population, a composition for marking the pathogenic cells population and pharmaceutical composition
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机译:用于增强特异性消除病原细胞群的药物组合物,用于标记病原细胞群的组合物和药物组合物
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摘要
A method and pharmaceutical composition are provided for enhancing the endogenous immune response-mediated elimination of a population of pathogenic cells in a host animal wherein the pathogenic cells preferentially express, uniquely express, or overexpress a binding site for a particular ligand. The invention comprises administering the ligand conjugated to an immunogen to a host animal harboring the population of pathogenic cells. Antibodies, preexisting or administered to the host animal to establish a passive immunity, directed against the immunogen bind to the ligand-immunogen conjugate resulting in elimination of the pathogenic cells by the host's immune response. At least one additional therapeutic factor is administered selected from the group consisting of a cell killing agent, a tumor penetration enhancer, a chemotherapeutic agent, antimicrobial agent, a cytotoxic immune cell, and a compound capable of stimulating an endogenous immune response wherein the compound does not bind to the ligand-immunogen conjugate.
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