A process for producing 2,3,4,5-tetrafluorobenzoYlfluoride and 2,3,4,5-tetrafluorobenzoTrifluoride

摘要

A process for producing 2,3,4,5-tetrafluorobenzoylfluoride and 2,3,4,5-tetrafluorobenzotrifluoride, important intermediate products in the synthesis of medicaments, by an interaction of 2,3,4,5-tetrachlorobenzoylchloride (2,3,4,5-tetrachlorobenzotrifluoride) with potassium fluoride in the absence of dissolvent in two stages at the temperature of 160-205оС in the presence of catalyst of the general formula EMBED ISISServer , wherein R1-R4 = СН3-С21Н43, С6Н5; R1=R2=R3=R4 or R1 EMBED Equation.3 R2 EMBED Equation.3 R3 EMBED Equation.3 R4; Х = Сl, Вr, I, РО EMBED Equation.3 , SO EMBED Equation.3 , СО EMBED Equation.3 , СН3СОO-, and cocatalyst - one of the following organic compounds: freon-11, freon-12, freon-112, freon-113, dimethylformamide, N-methylpyrrolidone, dimethylacetamide, dimethylsulfoxide, dialkyl ethers, chloroform, methylenechloride, monoglyme, diglyme, hexametalol, hexaethylphosphorotriamide, acetonitrile, dioxane, pentafluorethane, perfluoralkanes, tetrahydrofuran at the molar ratio of components equal to 2,3,4,5-tetrachlorobenzoylchloride or 2,3,4,5-tetrachlorobenzotrifluoride:catalyst: cocatalyst = 1:(0,01-0,1):(0,01-0,02) respectively. These conditions provide for output of objective substances between 75 % and 87 % with a possibility of regeneration of catalyst at the first stage of fluorination, reducing reaction temperature by 20-30oC and exclusion of use of expensive dissolvent - sulfolane.