METHOD FOR IMMUNOMODULATING THERAPY IN SURGICAL PATIENTS

摘要

The method for immunomodulating therapy in the surgical patients provides for diagnosing the systemic inflammatory reaction by assaying IL-8 content in blood serum of the patient. In the cases of the severe acute surgical states IL-8 is blocked by dexamethasone administered at a dose of 2-4 mg/kg daily. In addition, the density of HLA-DR+ receptors and type of the immune reactions are assessed. Then the systemic inflammatory reaction is additionally blocked in one of the following ways: When thereceptor density is high, and the immune reactions are of combined type û pentoxyphyllin is administered at a daily dose of 3 mg/kg for 3-5 days. When the receptor density is high, and the immune reactions are of humoral type û plasmapheresis is additionally used. When the receptor density is low, and the immune reactions are of cellular type û the cryoconserved hemopoietic embryonic cells (10-12 weeks of gestation) are administered (1-2 doses with 7-10-days interval). When the receptor density is low, and the immune reactions are of humoral type û the cryoconserved hemopoietic embryonic cells (16-18 weeks of gestation) are additionally used (1-2 doses with 7-10-days interval).