STABILIZED ENTERIC-COATED MICROGRANULES COMPRISING 2-(4-METHOXY-3-METHYL)-2-PYRIDINYL METHYLSULFINYL-5-(1H-PYRROL-1-YL)-1H-BENZIMIDAZOLE AND ORAL FORMULATIONS COMPRISING THE MICROGRANULES

摘要

ABSTRACT OF DISCLOSURE STABILIZED ENTERIC-COATED MICROGRANULES COMPRISING 2-[(4-METHOXY 3-METHYL)-2-PYRIDINYL]METHYLSULFINYL-5-(1H-PYRROL-1-YL)-1H BENZIMIDAZOLE AND ORAL FORMULATIONS COMPRISING THEMICROGRANULESThe present invention provides stabilized enteric-coated microgranules having the particle size of 350 to 840 um prepared by mixing 2-[(4-methoxy-3-methyl)-2-pyridinyl]methylsulfinyl-5-(1H- pyrrol-1- yl)-1H-benzimidazole as an active ingredient, alkali compound as a stabilizer, and a pharmaceutically acceptable additive, firstly coating the mixture with a film forming material to obtain microgranules, and secondly coating the microgranules with an enteric coating material, and formulations for oral administration comprising the stabilized enteric-coated microgranules