THIOCOLCHICINE DERIVATIVES WITH ANTI-INFLAMMATORY AND MUSCLE-RELAXING EFFECT

摘要

The present invention relates to 3-demethyl-thiocolchicine derivatives of general formula (I) CHEM in which R can be CHEM HOCH2-CHOH-CH2-, H2NCH2CHOHCH2-, HOOCCH2-, OH-CH2-CHCl-CH2-, to a process for the preparation thereof, to pharmaceutical compositions containing them and to the use thereof for the preparation of medicaments with muscle relaxant and antiinflammatory activities.