首页>
外国专利>
ANTIGENT FRAGMENT OF THE TAGA GENE AND METHODS FOR DETECTING THE PREDISPOSITION OF STOMACH Ulcer and Gastric Carcinoma
ANTIGENT FRAGMENT OF THE TAGA GENE AND METHODS FOR DETECTING THE PREDISPOSITION OF STOMACH Ulcer and Gastric Carcinoma
展开▼
机译:AI牛基因的抗原片段及胃溃疡和胃癌易感性的检测方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention provides an isolated nucleic acid encoding an approximately 120-128 kilodalton antigen of Helicobacter pylori, or an antigenic fragment thereof, wherein the antigen is associated with peptic ulceration. The present invention also provides methods of detecting the presence of a Helicobacter pylori strain possessing the 120-128 kilodalton antigen in a subject, comprising the steps of contacting an antibody-containing sample from the subject with a detectable amount of the tagA antigen or antigenic polypeptide of the present invention and detecting the binding of the antigen or fragment and the antibody. The detection of a strain expressing the TagA antigen is an indication of predisposition to peptic ulceration and gastric carcinoma. A mutant H. pylori not expressing a functional TagA antigen is also provided.
展开▼