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CLEANING METHOD OF CONNECTED IG FRACTIONS WITH IMMUNOMODULATING ACTIVITY
CLEANING METHOD OF CONNECTED IG FRACTIONS WITH IMMUNOMODULATING ACTIVITY
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机译:具有免疫调节作用的连接IG馏分的清洁方法
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摘要
The invention concerns a method for preparing Ig fractions from human polyvalent intravenous Immunoglobulins (IV Ig) which are in particular likely to be responsible for the immunomodulatory effect observed during the treatment of certain autoimmune diseases. The invention concerns Ig fractions having reactivity to IgM, IgG F(ab')2 or DNP hapten and no or little reactivity to non-self antigens, that is Ig fractions which have idiotypic interactions among themselves (connected fraction) or which include natural antibodies reacting with the DNP hapten. Said fractions exhibit a polyreactivity to specific autoantigens.
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