COMPLEXES OF INCLUSION OF AMINO ACID SALES FROM BENCIMIDAZOL DERIVATIVES WITH CYCLODEXTRINES, ITS PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING SUCH COMPLEXES.

摘要

Stable inclusion complex of an amino acid salt of a benzimidazole derivative and of a cyclodextrin, obtainable by the process comprising the steps of: a. dissolve the amino acid in water or in a mixture of ethanol: water; b. add the benzimidazole derivative to this solution; c. mix the solution at high speed for 1 to 10 minutes; d. add a cyclodextrin to the solution obtained in step C while maintaining strong stirring for 0.5 to 24 hours; and. Prepare the final stable inclusion complex by a method selected from spray drying, lyophilization, evaporation of the solvent under reduced pressure, by deposition on inert cores or by a granulation process, to obtain tablets or pellets by extrusion-spheronization.