BENZOFURILPIPERAZINAS: SEROTONINE 5-HT2C RECEPTOR AGONISTS.

摘要

The compounds of ** formula ** A is a piperazine R is hydrogen, halo, trifluoromethyl or C1-C6 alkyl; R1 is hydrogen, halo, trifluoromethyl, phenyl or C1-C6 alkyl; R2, R3 and R4 are independently hydrogen, halo, dihalomethyl, trifluoromethyl, 1,1,1-difluoroet-1-yl, cyano, C1-C4 alkoxy, C1-C4 alkoxycarbonyl, C1-C6 alkyl, -C (O) NHR9 or C1-C6 alkyl substituted with a substituent selected from the group consisting of halo, C1-C4 alkoxy and hydroxy. R5, R6, R7 and R8 are independently hydrogen, C1-C6 alkyl, phenyl, benzyl, hydroxymethyl, halomethyl, dihalomethyl, trihalomethyl or benzyloxymethyl. or pharmaceutically acceptable acid addition salts thereof.