PROCEDURES FOR SELECTION AND PRODUCTION OF PEPTIDIC EPITHOPES OF T-LYMPHOCYTES AND VACCINES CONTAINING THE INDICATED SELECTED EPITHOPES.

摘要

THE PRESENT INVENTION REFERS TO THE FIELD OF MOLECULAR BIOLOGY AND IMMUNOLOGY. IN PARTICULAR, IT CONCERNS VACCINES AND PROCEDURES TO PROVIDE VACCINES THAT CAUSE IMMUNE ANSWERS WHEN ADMINISTERED TO A MAMMAL, IN PARTICULATE A HUMAN BEING. THE PREFERRED PROMISED IMMUNE RESPONSE IS A RESPONSE OF T-CELLS, INDUITED BY EPITHOPES OF PEPTIDIC T-CELLS. THESE VACCINES CAN BE APPLIED IN MANY FIELDS, THAT GO FROM THE TREATMENT OF CANCER TO THE TREATMENT OR PROFILAXIS OF INFECTIOUS DISEASES SUCH AS AIDS. THIS INVENTION PROVIDES NEW PROCEDURES FOR CHOOSING THE SEQUENCES OF PEPTIDES FROM AN INTACT ANTIGEN THAT LEADS TO AN ADEQUATE IMMUNE RESPONSE (CELL T) TO ITS ADMINISTRATION IN AN APPROPRIATE VEHICLE OR EXCIPIENT. THE EPITOPES AND THE VACCINES, NATURALLY, ARE ALSO PART OF THE PRESENT INVENTION.