TREATMENT OF PARTIAL INSENSITIVITY TO GROWTH HORMONE.

摘要

PROCEDURES ARE DESCRIBED FOR INCREASING THE RATE OF GROWTH OF A HUMAN PATIENT WHO HAS THE PARTIAL INSENSITIVITY SYNDROME TO THE GROWTH HORMONE, BUT NOT THE LARON SYNDROME. ONE OF THESE PROCEDURES UNDERSTANDS THE ADMINISTRATION TO THE PATIENT OF AN EFFECTIVE DOSE OF GROWTH HORMONE, PREFERENTLY HORMONE OF GROWTH WITH A NATIVE HUMAN SEQUENCE, WITH OR WITHOUT A NON-TERMINAL METIONIN. THE PATIENT IS CHARACTERIZED BY HAVING A HEIGHT LESS THAN APPROXIMATELY -2 TYPICAL DEVIATIONS BELOW THE NORMAL FOR ITS AGE AND SEX, A SERIOUS LEVEL OF FIXING PROTEIN FOR GROWTH HORMONE WITH HIGH AFFECTION AT LEAST 2 DEVIATIONS BY TIP NORMAL LEVELS, A SERIOUS LEVEL OF IGF - I LOWER THAN NORMAL MIDDLE LEVELS, AND A SERIOUS LEVEL OF GROWTH HORMONE THAT IS AT LEAST NORMAL. IN ANOTHER OF THESE PROCEDURES, THE SAME PATIENT POPULATION IS TREATED WITH AN EFFECTIVE AMOUNT OF IGF - I, ADMINISTERED ONLY OR IN COMBINATION WITH A QUANTITY OF GROWTH HORMONE THAT IS EFFECTIVE IN COMBINATION WITH THE IGF - I.