ENDOTHELINE ANTOGONIST: N - ((2`. ((4,5-DIMETIL-3-ISOXAZOLIL) AMINO) SULFONIL) -4- (2-OXAZOLIL) 2,2-BIFENIL) -2-IL (METIL) -N , 3,3, TRIMETHYLBUTANAMIDE AND N- (4,5-DIMETHYLISOXAZOLIL) -2` - ((3,3-DIMETIL-2-OXO-1-PIRROLIDINIL) METHYL) -4`- (2-OXAZOLIL) (1, 1`-BIFENIL) -2-SULFONAMIDAY ITS SALTS.

摘要

The compounds N - {[} {[} 2 {sup, ''} - {[} {[} {(} 4,5-dimethyl-3-isoxazolyl {amino {]} sulfonyl {]} -4 - {( } 2-oxazolyl {{[} 1,1 {sup, ''} - biphenyl {]} -2-yl {]} methyl {]} - N, 3,3-trimethylbutanamide and N - {(} 4,5 -dimethyl-3-isoxazolyl {-2 {sup, ''} - {[} {(} 3,3-dimethyl-2-oxo-1-pyrrolidinyl {methyl {]} - 4 {sup, ''} - { (} 2-Oxazolyl {{[} 1,1 {sup, ''} -biphenyl {]} -2-sulfonamide and its salts are useful as endothelin antagonists.