Genetic testing to determine the lack of response to statin drug treatment.

摘要

A method of detecting genetic predisposition in a human subject to a lack of response to statin drug treatment for prevention of atherosclerotic stenosis, comprising: a) amplifying nucleic acids that include the normal locus of the recognition site for HindIII in intron 8 of the human gene for lipoprotein lipase (LPL) from a tissue sample collected from a human subject to obtain amplification products, and b) analyzing the amplification products for the absence of a recognition site for HindIII intron 8 of the human gene for lipoprotein lipase, wherein homozygosity for the absence of said HindIII recognition site indicates a genetic predisposition to non-responsiveness to statin drug treatment for prevention of atherosclerotic stenosis.