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Oral dosage forms retained in the stomach for controlled release of drugs poorly soluble and insoluble substance.

机译:保留在胃中的口服剂型,用于控制药物的难溶性和不溶性物质的释放。

摘要

ARE PRESENTED ORAL DOSAGE FORMS OF MEDICINES, controlled release comprising a tablet or capsule CONTAINING A SERIES OF A DRUG PARTICLE SOLID STATE POLYMER DISPERSED A ENGROSABLE / ERODIBLE, such as poly (ethylene oxide). ONCE ingested, tablet or capsule FOR aerosolize disintegrates IN THE STOMACH IN WHERE WATER imbibing SIZE AND PROMOTE INCREASED RETENTION IN PATIENTS IN THE PROCESS WHICH INDUCE. AS THE RETAINED gastrically dosage form erodes, the drug is released controllably IN THE STOMACH FOR TREATMENT OF LOCAL diseases and upper gastrointestinal tract where CONTROLLED AND MAY BE ABSORBED therapeutically. Can also be administered vesicles containing medications such as liposomes or nanoparticles or drug particles enteric coating to the gastrointestinal tract controllably USING DOSAGE FORMS GASTRIC RETENTION OF THE INVENTION.
机译:是药物的优选口服剂型,包括片剂或胶囊的控释制剂,所述片剂或胶囊包含一系列可分散/易溶的药物颗粒固态聚合物,例如聚环氧乙烷。一次吸入的片剂或胶囊剂会在吸入水的大小的气溶胶中崩解,并会增加患者体内保留率。随着保留的胃剂形式的侵蚀,该药物在控制和可能被吸收的局部疾病和上消化道的胃中可控地释放。还可使用含有胃肠道的剂量形式将含有诸如脂质体或纳米颗粒或药物颗粒肠溶衣的药物的囊泡可控地给药至胃肠道。

著录项

  • 公开/公告号ES2213836T3

    专利类型

  • 公开/公告日2004-09-01

    原文格式PDF

  • 申请/专利权人 DEPOMED INC.;

    申请/专利号ES19970942616T

  • 发明设计人 LOUIE-HELM JENNY;SHELL JOHN W.;

    申请日1997-09-18

  • 分类号A61K9/22;A61K9/52;

  • 国家 ES

  • 入库时间 2022-08-21 23:05:26

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