METHOD OF MANUFACTURING T-20 AND T-1249 PEPTIDES AT COMMERCIAL SCALE, AND T-20 AND T-1249 COMPOSITIONS RELATED THERETO

摘要

The present invention relates to an improved process for making commercialquantities of a T-20 or a T-1249 composition, or a fragment of a T-20 or a T-1249composition. The improvement includes using a low void space resin and/or asurfacefunctionalized resin optionally loaded with an amino acid or amino acidderivative tocreate one or more T-20 or T-1249 fragments.