ADENOVIRUS SEROTYPE 24 VECTORS, NUCLEIC ACIDS AND VIRUS PRODUCED THEREBY

摘要

Adenoviral serotypes differ in their natural tropism. The various serotypes ofadenovirus have been found to differ in at least their capsid proteins (e.g.,penton-base and hexon proteins), proteins responsible for cell binding (e.g.,fiber proteins), and proteins involved in adenovirus replication. Thisdifference in tropism and capsid proteins among serotypes has led to the manyresearch efforts aimed at redirecting the adenovirus tropism by modificationof the capsid proteins. The present invention bypasses such requirement forcapsid protein modification as it presents a recombinant, replication-defective adenovirus of serotype 24, a rare adenoviral serotype, and methodsfor generating the alternative, recombinant adenovirus. Additionally, means ofemploying the recombinant adenovirus for the delivery and expression ofexogenous genes are provided.