SPLICE VARIANTS OF HUMAN VOLTAGE-GATED CALCIUM CHANNEL ALPHA2DELTA-2 SUBUNIT DESIGNATED-ALPHA2DELTA2-A AND ALPHA2DELTA2-B

摘要

The invention provides novel nucleic acid molecules of an alternative splicingvariant of a human calcium channel subunit .alpha.2.delta.-2. Also providedare the gene products of the nucleic acid molecules, antibodies specificthereto and methods of using the polynucleotides or polypeptides to identifymedicaments useful for treating pathological disorder characterized byaberrant calcium influx mediated by one or both of the .alpha.2.delta.-subunit isoforms disclosed herein. Pharmaceutical compositions containing, asan active ingredient expression vectors comprising any one or both of thepolynucleotides or encoded proteins are also provided.