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PREPARATION OF D-(-) -1-SUBSTITUTED PHENYL-2-DICHLORO-ACETOAMINO-3FLUORO-1-PROPANOL FROM L TYPE SUBSTITUTED PHENYL SERINE ESTER
PREPARATION OF D-(-) -1-SUBSTITUTED PHENYL-2-DICHLORO-ACETOAMINO-3FLUORO-1-PROPANOL FROM L TYPE SUBSTITUTED PHENYL SERINE ESTER
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机译:由L型取代的苯基丝氨酸酯制备D-(-)-1-取代的苯基-2-二氯乙酰氨基3氟-1-丙醇。
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摘要
The process of the present invention prepares D-(-)-Su's-substituted phenyl-2-dichloro acetoamino-3-fluoro-1-propanol by using L type substituted phenyl serine ester extracted and purified from resolution waste liquid as raw material and through stepped reactions. The process is simple, high in yield, low in cost and complete in configuration and is one effective and simple method of conversion from L type substituted phenyl serine ester to D type fluorothiamphenicol. The present invention solves the problem of disposing waste antimer produced in the resolution process of producing flunikan, and can reduce environmental pollution and has certain practical significance.
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