GENE EXPRESSION PROFILING OF ADULT SOFT TISSUE SARCOMA

摘要

The present invention develops a genome-based classification scheme for adult soft tissue sarcomas. Synovial sarcomas, round cell//myxoid liposarcomas, clear cell sarcomas and gastrointestinal stromal tumors displayed remarkably distinct and homogenous gene expression profiles. Notably, a subset of malignant fibrous histiocytomas, controversial histologic subtype, was identified as a distinct genomic group. The classification scheme would have implications for diagnosis and provides potential new therapeutic targets of soft tissue sarcoma.