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METHOD FOR PREDICTING A DRUG TRANSPORT CAPABILITY BY ABCG2 POLYMORPHISMS
METHOD FOR PREDICTING A DRUG TRANSPORT CAPABILITY BY ABCG2 POLYMORPHISMS
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机译:ABCG2多态性预测药物运输能力的方法
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摘要
The present invention provides polymorphisms of ABCG2 polypeptide and polynucleotide coding therefor, which is related to the intracellular accumulation of indolocarbazole compounds, as well as methods for detecting the polymorphisms, comprising collecting a sample from mammals, and determining a polymorphism of the nucleotide sequence of ABCG2 gene or a polymorphism of the amino acid sequence of ABCG2 polypeptide.In a preferred embodiment of the present invention, the polymorphism of the nucleotide sequence is one or more of single nucleotide polymorphisms at positions selected from the group consisting of 34, 376 and 421 of SEQ ID NO:1, and the polymorphism of the amino acid sequence is one or more of amino acid polymorphisms at positions consisting of 12, 126, and 141 of SEQ ID NO:2.
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机译:本发明提供了与吲哚并咔唑化合物的细胞内蓄积有关的ABCG2多肽的多态性及其编码的多核苷酸,以及检测该多态性的方法,该方法包括从哺乳动物中收集样品并确定ABCG2的核苷酸序列的多态性。在本发明的一个优选的实施方案中,核苷酸序列的多态性是选自以下的位置中的一个或多个单核苷酸多态性:34、376和421的ABCG2多肽的氨基酸序列的多态性。 SEQ ID NO:1,并且该氨基酸序列的多态性是由SEQ ID NO:2的12、126和141组成的位置处的一个或多个氨基酸多态性。
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