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DIAGNOSTIC AND THERAPEUTIC USE OF PROTEOLIPID PROTEIN FOR ALZHEIMER'S DISEASE
DIAGNOSTIC AND THERAPEUTIC USE OF PROTEOLIPID PROTEIN FOR ALZHEIMER'S DISEASE
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机译:蛋白脂蛋白在阿尔茨海默氏病中的诊断和治疗应用
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摘要
The present invention discloses the differential expression of the PLP gene coding for PLP/DM20 protein in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using a PLP gene and its corresponding gene products. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
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