Derivatives of triptolide having high immunosuppressive effect and high water solubility, and uses thereof

摘要

The present invention provides water soluble triptolide derivatives of formula I, II, IIIa, and IIIb, which have high immunosuppressive activity and in which R1 and R2 have the same meanings as defined in claims. The present invention also provides chemically synthetic methods of the triptolide derivatives of formula I, II, IIIa, and IIIb, and the use of the triptolide derivatives in the treatment of autoimmune deficiency diseases and inflammatory diseases correlated with immunosuppression. CHEM CHEM