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A METHOD OF PREVENTION OF LYSOSOMAL LEAKAGE IN EUKARYOTIC CELLS BY USING 6-METHYLURACIL BASED WATER-SOLUBLE COMPOUNDS AND METHOD OF PRODUCING AND USE THEREOF
A METHOD OF PREVENTION OF LYSOSOMAL LEAKAGE IN EUKARYOTIC CELLS BY USING 6-METHYLURACIL BASED WATER-SOLUBLE COMPOUNDS AND METHOD OF PRODUCING AND USE THEREOF
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机译:一种基于6-甲基尿嘧啶的水溶性化合物预防真核细胞溶酶体渗漏的方法及其制备和使用方法
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摘要
A composition and method of preventing a lysosomal leakage from eukaryotic cells is based on a 6-methyluracil based water-soluble compound. The cells are being exposed to a water solution of such compound for the duration of a sub-optimal condition such as a temperature shock, starvation, radiation, etc. The optimum concentration of the compound is ranging from 1 to 1000 micrograms per milliliter of a solution. The preferred concentration is from 10 to 500 mkg/ml. The most advantageous composition from the group is a complex of 2,4-dihydroxy-6-methylpyrimidine with N-methyl-D-glucamine. Besides cell preservation, the composition is useful for a treatment of a variety of medical conditions characterized by excessive or inappropriate apoptosis such as ischemia, type 1 diabetes, stroke, Alzheimer's, and Parkinson's diseases. The composition is also useful in yeast production, food preservation, and other applications.
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