METHODS FOR BLOCKING ADIPOCYTE DIFFERENTIATION AND TRIGLYCERIDE ACCUMULATION WITH DUAL-SPECIFICITY TYROSINE- (Y) - PHOSPHORYLATION REGULATED KINASE 4 (DYRK4) INHIBITORS

摘要

Methods for blocking adipocyte differentiation and triglyceride accumulation with inhibitors of DYRK4 are provided. DYRK4 inhibitors of the present invention include small molecules, antibodies, peptides (including dominant negative peptides) and antisense compounds, including ribozymes, inhibitory RNA molecules including siRNA molecules and antisense oligonucleotides.