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STEM CELL EXPANSION FACTOR BLOCKING A GENE LIMITING HOX-INDUCED EXPANSION AND METHOD THEREOF
STEM CELL EXPANSION FACTOR BLOCKING A GENE LIMITING HOX-INDUCED EXPANSION AND METHOD THEREOF
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机译:阻止基因限制HOX诱导的STEM细胞扩增因子及其方法
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摘要
The present invention relates to a stem cell expansion factor comprising a blocker which reduces expression level of at least one gene normally limiting HOX-induced expansion of stem cells, whereby reducing expression level of said gene enhances expansion of stem cells containing a HOX peptide. The present invention also relates to a composition for enhancing expansion of stem cells comprising an amino acid sequence having the activity of a HOX peptide, wherein said peptide being able to cross a cell membrane, and a blocker which reduces expression level of at least one gene normally limiting HOX-induced expansion of stem cells, whereby reducing expression level of said gene in the presence of a HOX peptide enhances expansion of stem cells. The preferred HOX peptide is HOXB4 and the preferred gene is PBX.
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