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CYTOPLASMIC DYNEIN HEAVY CHAIN 1 GENES, EXPRESSION PRODUCTS, NON-HUMAN ANIMAL MODEL: USES IN HUMAN NEUROLOGICAL DISEASES
CYTOPLASMIC DYNEIN HEAVY CHAIN 1 GENES, EXPRESSION PRODUCTS, NON-HUMAN ANIMAL MODEL: USES IN HUMAN NEUROLOGICAL DISEASES
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机译:细胞膜动力蛋白重链1基因,表达产物,非人类动物模型:在人类神经疾病中的应用
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摘要
A non-human animal model is provided, particularly a mouse model for movement hyperactivity, excitoxicity disorders (e.g. myoclonic cramping) and neurodegeneration, in which modified cytoplasmic dynein heavy chain1 is expressed. Modified human and mouse cytoplasmic dynein heavy chain1 proteins and nucleic acids are also provided, including the corresponding recombinant proteins. The invention further provides uses for the non-human animal model and the modified cytoplasmic dynein heavy chain1 proteins and nucleic acids, in particular for the diagnosis and treatment of medical conditions associated with over-expression of cytoplasmic dynein heavy chain1.
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