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In vitro and in vivo models for screening compounds to prevent glucocorticoid-induced bone destruction
In vitro and in vivo models for screening compounds to prevent glucocorticoid-induced bone destruction
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机译:用于筛选可预防糖皮质激素诱导的骨破坏的化合物的体外和体内模型
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摘要
The present invention demonstrates that glucocorticoid-induced bone disease is due to changes in the birth and death rate of bone cells using a murine model of glucocorticoid excess as well as bone biopsy specimens obtained from patients with glucocorticoid-induced osteoporosis. This invention demonstrates that glucocorticoid administration increases apoptosis of mature osteoblasts and osteocytes and decreases bone formation rate and bone mineral density accompanied by defective osteoblastogenesis and osteoclastogenesis in the bone marrow.
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