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NOVEL USE OF CERTAIN INSULIN SENSITIZERS OR PPAR-GAMMA AGONISTS
NOVEL USE OF CERTAIN INSULIN SENSITIZERS OR PPAR-GAMMA AGONISTS
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机译:某些胰岛素增敏剂或PPAR-γ激动剂的新型使用
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摘要
A use of certain insulin sensitiser or a PPAR gamma agonist such as a compound of formula (I) or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof, and/or a pharmaceutically acceptable solvate thereof, wherein: A1 represents a substituted or unsubstituted aromatic heterocyclyl group; R1 represents a hydrogen atom, an alkyl group, an acyl group, an aralkyl group, wherein the aryl moiety may be substituted or unsubstituted, or a substituted or unsubstituted aryl group; R2 and R3 each represent hydrogen, or R2 and R3 together represent a bond; A2 represents a benzene ring having in total up to five substituents; and n represents an integer in the range of from 2 to 6, for the manufacture of a medicament for treatment and/or prophylaxis of diseases associated with loss of bone mass, such as osteoporosis and related osteopenic diseases, Paget's disease, hyperparathyroidism and related diseases.
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机译:某些胰岛素敏化剂或PPARγ激动剂,例如式(I)化合物或其互变异构形式和/或其药学上可接受的盐和/或其药学上可接受的溶剂化物的用途,其中:A 1表示取代或未取代的芳族杂环基; R 1表示氢原子,烷基,酰基,芳烷基,其中芳基部分可以是取代或未取代的,或取代或未取代的芳基; R 2和R 3分别表示氢,或者R 2和R 3一起表示键。 A 2表示总共具有至多五个取代基的苯环; n表示2至6之间的整数,用于制造用于治疗和/或预防与骨量减少有关的疾病的药物,所述疾病例如骨质疏松症和相关的骨质疏松症,Paget病,甲状旁腺功能亢进症和相关疾病。
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