PROTEIN-PROTEIN INTERACTIONS BETWEEN SHIGELLA FLEXNERI POLYPEPTIDES AND MAMMALIAN POLYPEPTIDES

摘要

The present invention relates to protein-protein interactions between Shigella polypeptides and mammalian polypeptides. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies, to the complexes, Selected Interacting Domains (SID3) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical composition that are capable of modulating the protein-protein interactions.