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ANTAGONISTS OF MEGALIN OR CUBILIN FOR USE IN PREVENTING ORGAN DAMAGE INDUCED BY THERAPEUTIC AGENTS
ANTAGONISTS OF MEGALIN OR CUBILIN FOR USE IN PREVENTING ORGAN DAMAGE INDUCED BY THERAPEUTIC AGENTS
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机译:麦加林或小甜瓜的拮抗剂,用于预防治疗剂引起的器官损伤。
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摘要
The invention relates to agents for the prevention of organ damage, in particular of the kidneys and the inner ear, induced by the administration of aminoglycosides. Agents according to the invention are all substances which are megalin and/or cubilin antagonists (inhibitors). In particular, these are molecules (compounds) having polybasic structures which bind to megalin and inhibit the binding of aminoglyco-sides and related substances.
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