ANTIPROLIFERATIVE PROTEIN FROM HYPERICUM PERFORATUM AND NUCLEIC ACIDS ENCODING THE SAME

摘要

A protein named CHP-10 has been isolated from Hypericum perforatum callus culture. This protein comprises a unique 20 amino acid sequence, has an apparent molecular weight of approximately 39 kDa by SDS-PAGE, and inhibits proliferation of abnormally proliferating cells from cancer or non-cancerous proliferative disorders. Methods of using CHP-10, or fragments, derivatives, homologs and analogs of CHP-10, to inhibit the proliferation of abnormally proliferating cells are also provided.