首页>
外国专利>
LABEL-FREE DETECTION OF SINGLE NUCLEOTIDE POLYMORPHISMS USING SURFACE PLASMON RESONANCE IMAGING
LABEL-FREE DETECTION OF SINGLE NUCLEOTIDE POLYMORPHISMS USING SURFACE PLASMON RESONANCE IMAGING
展开▼
机译:利用表面等离子体共振成像无标签检测单核苷酸多态性
展开▼
页面导航
摘要
著录项
相似文献
摘要
Disclosed are methods of using structure-specific, invasive nucleic acid cleavage reactions, in an addressed array format, to detect polymorphisms in general, and single nucleotide polymorphisms in particular. In the preferred embodiment of the invention, the addressed array format utilizes surface plasmon resonance imaging as a means for detecting the products of the invasive cleavage reaction and hence the presence of polymorphisms in the target nucleic acid. Sensitivity of the SPR detection is further enhanced by rolling circle amplification of the bound cleavage products.
展开▼