ERBIN AS A NEGATIVE REGULATOR OF RAS-RAF-ERK SIGNALING

摘要

The instant invention provides a method of inhibiting proliferation of maligant cells by administration of a Rasactivity inhibitory effective amount of DNA which encodes the protein Erbin into the maligant cells. The invention also provides methods for evaluating proliferative properties and progression of proliferative activities in tumor cells by measurement of Erbin in tumor tissue.