METHOD AND PROGRAMMABLE ILLUMINATION DEVICE FOR HIGH-RESOLUTION, MASSIVELY PARALLEL SPATIAL SYNTHESIS AND ANALYSIS OF MICROARRAYS

摘要

The invention relates to a method and to a programmable illumination device for high-resolution, massively parallel spatial synthesis or analysis of microarrays. The invention makes it possible to generate a two-dimensional structured laser light spot-based pattern in a spatial time and wavelength multiplex method. Said spot-based patterns are defined on grids, can amount to 10000 100000 light spots per square centimetre and be used to deposit substances on the illuminated positions of the light patterns on fixed surfaces. The illumination device can also be used to illuminate microarrays with specified chronological sequences of two-dimensional laser light spot patterns with various wavelengths and to produce fluorescent effects for analysis methods. The invention consists in carrying out digital transmission functions by means of electrically switchable, microstructured lenses which produce specified laser light spot patterns in a time multiplexing method by illumination with a laser light source using a diffraction effect on a defined image plane.