Programmable lighting device for high-resolution, massive parallel, spatial systhese and analysis of microarrays

摘要

The invention relates to a method and a programmable lighting device for high-resolution, massive parallel, spatial synthesis or analysis of microarrays. The quality of the production and analysis of microarrays, and biochips depends significantly on the quality of the illumination methods, that is to say from the resolution capability, the flexible applicability and the degree of parallelism in the production of array patterns, ab. The invention makes it possible, according to a specification, two-dimensional structured laser light - dot pattern in a space -, time - and wavelengths - multiplex procedure to produce. This dot pattern are defined on screens, it is easy to 10000 to 100000 light points per square centimeter, and have to be used for this purpose, substances to the illuminated positions of the pattern of light on solid surfaces to be deposited. The illumination device can also be used to prevent microarrays with specified chronological sequences of two-dimensional laser light - dot pattern with different wavelengths and to produce fluorescent effects for analysis methods. The invention includes the realization of digital transmission functions by means of an electrically switchable, microstructured optics, which by illumination with a laser light source and under utilization of the diffraction effect in a defined plane of the laser light - dot pattern, which is specified in the time-division multiplex - the method ..